In goblet cells, which organelle is especially prominent for mucin production?

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Study for the NBME Histology Test. Access flashcards and multiple choice questions, each with hints and explanations. Prepare effectively for your exam!

Multiple Choice

In goblet cells, which organelle is especially prominent for mucin production?

Explanation:
Mucin production in goblet cells hinges on the Golgi apparatus, which handles the specialized processing and packaging of these large glycoproteins. Mucins are synthesized initially on ribosomes of the rough endoplasmic reticulum, but they undergo extensive glycosylation and sorting in the Golgi, where they are packaged into secretory granules for apical release. This makes the Golgi especially prominent in goblet cells. The nucleus and mitochondria aren’t directly involved in this secretory processing, and while the rough ER starts the synthesis, the final preparation for secretion occurs in the Golgi.

Mucin production in goblet cells hinges on the Golgi apparatus, which handles the specialized processing and packaging of these large glycoproteins. Mucins are synthesized initially on ribosomes of the rough endoplasmic reticulum, but they undergo extensive glycosylation and sorting in the Golgi, where they are packaged into secretory granules for apical release. This makes the Golgi especially prominent in goblet cells. The nucleus and mitochondria aren’t directly involved in this secretory processing, and while the rough ER starts the synthesis, the final preparation for secretion occurs in the Golgi.

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