Where are goblet cells most abundant and what is their function?

• A. Most abundant in respiratory and intestinal mucosa; they secrete mucus to trap particles and pathogens.
• B. They are most abundant in the epidermis; secrete keratin.
• C. They are most abundant in brain tissue; regulate ions.
• D. They secrete digestive enzymes in the pancreas.

Answer: (A)

Goblet cells are mucus-secreting unicellular glands that line mucous membranes, and they are most abundant in the respiratory and intestinal tracts. Their apical region is packed with mucin granules, and when released, mucus forms a protective, lubricating layer. In the airways, mucus traps dust, pathogens, and particles, helping with clearance alongside cilia. In the intestine, mucus protects the epithelium from mechanical stress and digestive enzymes and facilitates smooth passage of contents. They’re not found in the epidermis, where keratinocytes produce keratin; nor in brain tissue, where ion regulation is handled by neural and glial cells; nor in the pancreas, where digestive enzymes are released by acinar cells.