Where are parafollicular C cells located in the thyroid gland?

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Study for the NBME Histology Test. Access flashcards and multiple choice questions, each with hints and explanations. Prepare effectively for your exam!

Multiple Choice

Where are parafollicular C cells located in the thyroid gland?

Explanation:
Parafollicular C cells reside in the connective tissue between thyroid follicles—that is, in the interfollicular spaces within the thyroid stroma. They are not part of the follicular lumen or colloid, and they’re not located in the capsule or on the follicle surface. These neuroendocrine cells secrete calcitonin in response to high blood calcium, helping to lower calcium levels by inhibiting osteoclast activity. Histologically, you’ll find them as scattered, lighter-staining cells in the interfollicular tissue near blood vessels, embedded among the follicles rather than inside or around the follicular epithelium.

Parafollicular C cells reside in the connective tissue between thyroid follicles—that is, in the interfollicular spaces within the thyroid stroma. They are not part of the follicular lumen or colloid, and they’re not located in the capsule or on the follicle surface. These neuroendocrine cells secrete calcitonin in response to high blood calcium, helping to lower calcium levels by inhibiting osteoclast activity. Histologically, you’ll find them as scattered, lighter-staining cells in the interfollicular tissue near blood vessels, embedded among the follicles rather than inside or around the follicular epithelium.

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